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Neha posted an Question
August 06, 2020 • 17:16 pm 30 points
  • CSIR NET
  • Life Sciences

71. cyclins are the regulatory subunits and cyclin-dependent kinases (cdks) are the catalytic subunits, following diagram repre- sents the involvement of cyclin

71. Cyclins are the regulatory subunits and cyclin-dependent kinases (CDKs) are the catalytic subunits, Following diagram repre- sents the involvement of cyclins and CDKs in various stages of cell cycle: Cyclin B CDK G M Cyclin A G Cyclin D CDK 45 CDK 2 Cyclin E CDK 2 If we knock down cyclin D in a cell by shRNA, which one of the following graphs correctly represents the level of CDK2 activity ?

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    Narayan singh Best Answer

    you i think you know the cell is regulated by cdk and cyclin. cyclin,s are regulatory proteins. they regulates the activities of cdk. the cyclins can be synthesized and degreded throughout the cell cell cycle by proteosomal degradation. and CDKs are protein kinase, catalytic in nature and the activities of CDK depends on cyclin. main point is the concentration of CDK is always same (constant) but the activities is changed. then we comes on question- in the question they are knocked out cyclin D gene by siRNA. So the cyclin D can not form in the cell. and cyclin D regulate the activities of CDK 4,5 in G1 phase of the cell cycle. if Cyclin D is not form in G1 phase of cell cycle then cdk 4, 5 is inactive so the cell can not move into S phase of the cell cycle. so in the S phase cdk 2 activities remain zero or inactive in the cell cycle... because cell is not progressed in the S phase of cell cycle

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    Neha Gosai

    please... kindly give replies... faster...! as like other online classes do... give?

  • comment-profile-img>
    Narayan singh

    dear please update full questions... that question is incomplete..... blow the qu some graph are given below so please provide the graph for the proper explanation.

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    ohk

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