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Nilanjan Bhowmick AIR 3, CSIR NET (Earth Science)
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A mutation in the coding region of a mammalian gene leads to the loss of a single amino acid at the n-terminus of the nascent polypeptide. this is possible whe
A mutation in the coding region of a mammalian gene leads to the loss of a single amino acid at the N-terminus of the nascent polypeptide. This is possible when: (a) The mutation occurs at 3-end of coding strand (b) The mutation leads to shift of ribosome binding site (c) The first two codons code for methionine (d) The mutatioon leads to the introduction of premature stop codon
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Krishan k jakhad
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B. typical RBS sequence is located about 6 nucleotides upstream of a start codon in an mRNA. The ribosomal holoenzyme binds to both the RBS and the start codon. The start codon and everything downstream are translated by the ribosome. so a shift may leads to loss of N terminal amino acids.
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Dr. kirti
In this question, there is neither frame shift nor shorter fragment is formed .. therefore b, c & d options are not possible. Regarding option a... 3'-5' Coding strand forms 5'-3' mRNA with in turn codes for N- to C- terminal polypeptide. Since mutation is on N terminal which correspond to the 3' end of the coding strand. thus option a is correct