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Actinomycin D inhibits the process of transcription in both prokaryotic and eukaryotic organisms. The following statements are made about actinomycin D–mediated inhibition of transcription :
(A) Actinomycin D inhibits transcription from a double stranded DNA template by either E coli or yeast RNA polymerases.
(B) Actinomycin D inhibits transcription from a single stranded RNA template by eukaryotic viral RNA polymerases.
(C) Actinomycin D inhibits transcription from single stranded fx174 DNa template by E coli RNA polymerase immediately after viral DNA entry.
(D) Actinomycin D inhibits transcription from double stranded RNA template by eukaryotic RNA polymerase II.
Which of the combinations of the above statements is a true representation of the mechanism of actinomycin D mediated inhibition.
Actinomycin D is an intercalating compounds with sequence selectivity. The actinomycin chromophore favours guanine-cytosine pairs and is therefore inserted between the G-C step....