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Eduncle posted an MCQ
December 30, 2019 • 16:21 pm 0 points
  • CSIR NET
  • Life Sciences

Activation-induced cytidine deaminase (AID) is the key mediator of somatic hypermutation, gene conversion and class-switch recombination. In order to ascertain the role of AID in class-switch

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    Eduncle Best Answer

    Primary response always shows higher production of IgM whereas IgG expression occurs in secondary response, which is due to class switching mechanism. In the given graphs of IgM and IgG production, AID containing mouse should be able to perform class switching and as a result in secondary response will produce more amount of IgG compared to IgM. In case of AID deficient mouse there should not be any class switching as a result secondary response will not produce IgG. But it can still produce IgM in both primary and secondary response.

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