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An individual is having an inversion in heterozygous condition. The regions on normal chromosome are marked as A, B, C, D, E, F, G while the chromosome having inversion has the regions as a, b, c, d, e, f, g. the diagram given below shows pairing of these two homologous chromosomes during meiosis and the site of a crossing over is indicated :
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Eduncle Best Answer
A paracentric inversion does not include the centromere. Inversion heterozygotes during the first meiotic anaphase, the two centromeres migrate to opposite poles of the cell. Because of the crossover, one recombinant chromatid becomes stretched across the cell as the two centromeres begin to migrate in anaphase, forming a dicentric bridge—that is, a chromosome with two centromeres (a dicentric chromosome).
With continued migration, the dicentric bridge breaks due to tension. The other recombinant product of the crossover event is a chromosome without a centromere (an acentric fragment). This acentric fragment is unable to continue through meiosis and is usually lost. Thus, the only gametes that can give rise to viable progeny are those containing the chromosomes that did not involve crossing-over and gametes or zygotes derived from recombined chromatids are inviable.