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Eduncle posted an MCQ
December 30, 2019 • 15:37 pm 0 points
  • CSIR NET
  • Life Sciences

Eg5 is a well-studies protein in Xenopus. To understand the function of Eg5 in mammalian cells, a team of researchers treated mammalian cells during late G2 phase with Eg5-inhibitor. The following diagrams represent images of mitotic cells.

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    Eduncle Best Answer

    Eg5 is a Mitotic motor protein is the homotetrameric, plus-end directed kinesin, which is involved in separating the two centrosomes during spindle assembly. Eg5 consists of three domains, a motor head that has ATP binding capability and a C-terminal tail which has a MT binding domain, linked by a coiled-coil domain.
            Eg5 remains static in the midzone of spindle apparatus and important protein for the assembly but for the maintenance of the bipolar spindle. So Inhibition of Eg5 during spindle formation or at metaphase causes a monopolar spindle phenotype or spindle shortening, respectively

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