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Nilanjan Bhowmick AIR 3, CSIR NET (Earth Science)
Rachel Mary Clementina. J posted an Question
October 19, 2021 • 03:53 am
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30 points
30 points
- CSIR NET
- Life Sciences
Epidermal growth factor receptor for cancer development
kindly explain Epidermal growth factor receptor for cancer development
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The epidermal growth factor receptor protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations (changes) in the EGFR gene cause epidermal growth factor receptor proteins to be made in higher than normal amounts on some types of cancer cells. Mutations in EGF R have since been associated with a number of different cancers including non-small cell lung cancer, breast cancer, metastatic colorectal cancer and glioblastoma. Activation of EGF R leads to increased cell proliferation and cell growth and decreased programmed cell death (apoptosis). A substance that blocks the activity of a protein called epidermal growth factor receptor (EGFR). EGFR is found on the surface of some normal cells and is involved in cell growth. It may also be found at high levels on some types of cancer cells, which causes these cells to grow and divide.