S.m.d.abubakar Siddiq posted an Question
October 19, 2021 • 10:36 am 30 points
  • CSIR NET
  • Life Sciences

G6pd deficiency resistant to plasmodium why

glucose 6 phosphate dehydrogenase deficiency is found to be resistant to plasmodium why

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  • Priya sarda best-answer

    As G6PD deficiency leads to increased oxidative stress in red blood cells, this may in turn have a negative influence on the parasite. As such, individuals who possess this mutation have some protection against malaria. RBCs with low G6PD activity offer a hostile environment to parasite growth and thus an advantage to G6PD deficiency carriers. The counterpart of this protective effect is an increased susceptibility to oxidants such as some foods (fava beans), drugs (anti-malarial or sulphonamides), or various chemicals.

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