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Genes translocated to the heterochromatic regions of chromosomes are silenced. In S, pombe, a translocation event was detected wherein a gene of interest was translocated to the centromere region and is silenced. Mutagenesis leading to loss of function of the following target gene of interest was done to allow expression of the gene of interest from its new locus.
To express the gene,heterochromatinization, facilitated by HDACs (histone deacetylases) and HMTs (Histone methyl transferases) action, must be stopped through the mutagenesis in...