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Eduncle Best Answer
Milton begins his Book I of Paradise Lost with a prologue in which he performs the traditional epic task of invoking the Muse and stating his purpose. He invokes the classical Muse, Urania, but also refers to her as the "Heav'nly Muse," implying the Christian nature of this work.
In the grand invocation at the beginning of Book VII of his epic Paradise Lost, John Milton selects as his muse Urania, who is traditionally the Muse of Astronomy in classical texts.