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Nilanjan Bhowmick AIR 3, CSIR NET (Earth Science)
Rachel Mary Clementina. J posted an Question
October 19, 2021 • 03:56 am
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30 points
30 points
- CSIR NET
- Life Sciences
Insulin like growth factor receptor for cancer development
kindly explain Insulin like growth factor receptor for cancer development
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Insulin-like growth factor I (IGF-I) has significant structural homology with insulin. IGF-I has been shown to bind to insulin receptors to stimulate glucose transport in fat and muscle, to inhibit hepatic glucose output and to lower blood glucose while simultaneously suppressing insulin secretion. Insulin-like growth factors (IGFs) are essential for growth and survival that suppress apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in various cancers. The IGFs actions are mediated through the IGF-1 receptor that is involved in cell transformation induced by tumour. Independent of weight, insulin increases cell production and reduces cell death. That means there is more opportunity for something to go wrong and cancer to develop. Long-term increased insulin raises your risk for breast, prostate and colorectal cancers.