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Nilanjan Bhowmick AIR 3, CSIR NET (Earth Science)
Priya Lahorani posted an Question
December 30, 2021 • 03:22 am
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30 points
30 points
- CSIR NET
- Life Sciences
Please explain cis trans effect in pseudoalleles
please explain cis trans effect in pseudoalleles I don't know anything about it
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Priya sarda
To explain the action of these translocations, we propose dual position effect: Position effect of the cis type transforms the cell to malignancy, while position effect of the trans type permits the normal homologous chromosome to express a normal gene product.Let's start by discussing the meaning of “cis” and “trans.” The term cis is derived from the Latin root “cis,” meaning “the same side as.” In contrast, the term trans comes from the Latin root “trans,” meaning “across from.” Gene expression differences between species are driven by both cis and trans effects. Whereas cis effects are caused by genetic variants located on the same DNA molecule as the target gene, trans effects are due to genetic variants that affect diffusible elements. Previous studies have mostly assessed the impact of cis and trans effects at the gene level. However, how cis and trans effects differentially impact regulatory elements such as enhancers and promoters remains not understood. Here, we use massively parallel reporter assays to directly measure the transcriptional outputs of thousands of individual regulatory elements in embryonic stem cells and measure cis and trans effects between human and mouse.
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thankyou mam🙂
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Dr. sonal singh 1![best-answer]()
Pseudoalleles are the genes that are located close to each other, and similar in nature, and are genetically linked, which means that these two genes are nearly inherited together, and the functions are also nearly the same. So they appear to act as the same genes, hence they got the name Pseudoalleles. Characteristics of Pseudoalleles. - Some hypothesis states that Pseudoalleles are formed as a result of gene duplication. - These duplicated genes later can undergo the gene evolution, so that they develop new functions. - In some cases of Pseudoalleles, the two genes can be separated or it can be recombined. - Some of the characteristics of Pseudoalleles are, within the genes, they can cross over each other. And they can affect the same character. - Even though they cross over, the recombination which generally occurs is very low frequency. Example of pseudoalleles. - Lozenge eye in drosophila is one of the examples of Pseudoalleles. - Green and green had studied about the Lozenge eye in drosophila, where several alleles of the Lozenge gene are identified and Mapped together, and the mutant gene produces an eye with a glossy smooth surface. - In drosophila, all heterozygous carrying two mutants were lozenge in phenotype. - But the progeny of the heterozygous produce wild types of recombinants with a frequency higher than spontaneous mutations, indicating that those genes are Pseudoalleles. Pseudoalleles, exhibit Cis-Trans position effect, in the case of trans heterozygous, mutants of Pseudoalleles produce the mutant Phenotype, while the pseudoalleles of Cis heterozygous produce the wild Phenotype. Another example of the Pseudoalleles is the Star asteroid eye in drosophila.
thankyou mam🙂