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The skin is the largest organ of the body, with a total area of about 20 square feet. The skin protects us from microbes and the elements, helps regulate body temperature, and permits the sensations of touch, heat, and cold. Skin has three layers: The epidermis, the outermost layer of skin, provides a waterproof barrier and creates our skin tone. The dermis, beneath the epidermis, contains tough connective tissue, hair follicles, and sweat glands. The deeper subcutaneous tissue (hypodermis) is made of fat and connective tissue. The skin’s color is created by special cells called melanocytes, which produce the pigment melanin. Melanocytes are located in the epidermis. What are the seven most important layers of your skin? Stratum corneum. Stratum lucidum. Stratum granulosum. Stratum spinosum. Stratum basale. Dermis. Hypodermis. The skin appendages include sweat glands, nails, and the pilosebaceous unit of the skin, comprised of the hair shaft, hair follicle, sebaceous gland, and arrector pili muscle — these appendages derive from a down growth of the epidermis beginning in the third month of fetal life