Some Neurotransmitters Acetyicholine has an excitatory effect released from large pyramid cells from the motor cortex, basal gangilia, motor neurons entering skeletal muscles, preganglionic neurons of autonomous nervous system, postganglionic neurons of parasympathetic and sympathetic nenvous system. Norepinephrine secreted by the terminals of neurons located in brain stem and hypothalamus and function in overall activity and mood of the brain such as increasing the level of wakefulness. In most cases it activates excitatory neurons. Dopamine is secreted from the neurons of substantia nigra, a region of the brain whose neurons end in the basal ganglia and functions in inhibition. GABA is secreted from terminals in the spinal cords, cerebellum, basal ganglia and many areas of the cortex causing inhibition.