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Eduncle posted an MCQ
December 30, 2019 • 17:48 pm 0 points
  • CSIR NET
  • Life Sciences

The pedigree given below follows the inheritance pattern of a late-onset (after age of 30 years) genetic disease that is 100% penetrant. Affected individuals are indicated by a solid circle (woman) or solid square (males). RFLP analysis of DNA from each individual is shown below in the pedigree.

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    Eduncle Best Answer

    Careful observation of the pedigree RFLP pattern reveals diseased individuals are homozygous having two bands and heterozygous individuals have 3 bands who are phenotypically normal. So among III b IIIc and IIId, since both b and d have same two band RFLP pattern so they should show the diseased condition.

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