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In many plants the growing shoot apex inhibits the outgrowth of axillary buds, a phenomenon termed ‘apical dominance’. Removal of the shoot apex leads to the release of dormant axillary buds below it to form branches. Apical dominance allows plants to focus resources into the main axis of growth, while activation of dormant buds allows for recovery after damage or loss of the main shoot. It has been known for a long time that auxin is a major signal for apical dominance. If auxin is applied to a decapitated stump at the shoot apex, it can replace the growing apex in restoring branch inhibition. Auxin is mainly synthesized in the shoot apex in young leaves and subsequently transported basipetally (downwards from the tip to the base) in the polar auxin transport stream (PATS). Cytokinins represent a possible second messenger for auxin signalling in regulating bud activity. Endogenous CKs can be transported acropetally (towards the shoot apex) in the xylem sap, enter axillary buds and promote their outgrowth. Thus, CKs antagonize auxin in apical dominance.