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Eduncle Best Answer
Option B is correct because galactose binding proteins are capable of binding strongly to the oligosaccharide moiety of ganglioside GM1. Option C is correct because GM1 gangliosidosis is an autosomal recessive lysosomal storage diseases associated with a neurodegenerative disorder or dwarfism and skeletal abnormalities, respectively. These diseases are caused by deficiencies in the lysosomal enzyme beta-D-galactosidase (beta-Gal), which lead to accumulations of the beta-Gal substrates, GM1 ganglioside, and keratan sulfate. Beta-Gal is an exoglycosidase that catalyzes the hydrolysis of terminal beta-linked galactose residues. So, both galactose binding lectins and exoglycosidase have affinity to GM1 and can be utilized for localizing the gangliosides located on membrane surface.