Prakash Kumar posted an Question
July 09, 2021 • 15:44 pm 30 points
  • CSIR NET
  • Life Sciences

What is proteoglycans?

what is proteoglycans? write it's function. how it is synthesise in Human body.

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    Krishan k jakhad best-answer

    Proteoglycans are proteins that are heavily glycosylated with carbohydrates. The basic proteoglycan unit consists of a "core protein" with one or more covalently attached glycosaminoglycan (GAG) chain(s). The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge (e.g. chondroitin sulfate-GlcA-Gal-Gal-Xyl-PROTEIN). The Ser residue is generally in the sequence -Ser-Gly-X-Gly- (where X can be any amino acid residue but proline). The chains are long, linear carbohydrate polymers that are negatively charged under physiological conditions due to the occurrence of sulfate and uronic acid groups. Proteoglycans occur in connective tissue.

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