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Rachel Mary Clementina. J posted an Question
August 19, 2021 • 00:59 am
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30 points
30 points
- CSIR NET
- Life Sciences
What is the inducer of type 3 hypersensitivity
What is the inducer of type 3 hypersensitivity and factors which promote persistence of immune complexes
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Priya sarda Best Answer
In type III hypersensitivity reaction, an abnormal immune response is mediated by the formation of antigen-antibody aggregates called "immune complexes." They can precipitate in various tissues such as skin, joints, vessels, or glomeruli, and trigger the classical complement pathway. Type III hypersensitivity is induced by classic complement activation, caused by extracellular antibody–antigen complexes. Examples of type III hypersensitivity reactions include drug-induced serum sickness, farmer's lung and systemic lupus erythematosus. Factors determining the location of deposition and injury pattern include immunoglobulin class and subclass and the ability to activate complement and cellular immunity. Other factors include avidity, charge, size, ratio of antibody to antigen, as well as specificity, rate of production, and clearance