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Eduncle posted an MCQ
December 28, 2019 • 17:39 pm 0 points
  • CSIR NET
  • Life Sciences

Which one of the following assay systems can specifically detect apoptotic cells ?

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    Eduncle Best Answer

    Annexin V binds to phosphatidylserine (PS) in a calcium dependent manner. PS is normally only found on the intracellular leaflet of the plasma membrane in healthy cells, but
            during early apoptosis, membrane asymmetry is lost and PS translocates to the external leaflet. Fluorochrome-labeled Annexin V can then be used to specifically target and identify apoptotic cells.

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