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Eduncle Best Answer
Annexin V binds to phosphatidylserine (PS) in a calcium dependent manner. PS is normally only found on the intracellular leaflet of the plasma membrane in healthy cells, but
during early apoptosis, membrane asymmetry is lost and PS translocates to the external leaflet. Fluorochrome-labeled Annexin V can then be used to specifically target and identify apoptotic cells.