Time management is very much important in IIT JAM. The eduncle test series for IIT JAM Mathematical Statistics helped me a lot in this portion. I am very thankful to the test series I bought from eduncle.
Nilanjan Bhowmick AIR 3, CSIR NET (Earth Science)
Krishan k jakhad
Mannose 6 phosphate receptor over lysozyme(MPR) binds mannose 6-phosphate residues on lysosomal enzyme, both mannose and glucose are 6C sugars, almost similar structure (epimers) and are interconvertable by epimerase enzyme right. also M6P is very important for targeting Lysozyme enzyme to Lysosome organelle. now this is interesting 😀 to know both the absence of 2' OH and epimerization to G6P abolished recognition and binding of M6P by the receptor. receptor can recognise fructose 1 Phosphate but not G6P. therefore G6P is an ideal marker.
mannose 6 phosphate is important for targeting Lysozyme to Lysosome right if u replace with glucose 6 Phosphate it will not bind to receptor. simple
is mannose 6 phosphate ideal marker or glucose 6 phosphate?