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Yogita Basnal
Celluar respiration has 3 main steps. But if we include pyruvate decarboxylation also as a separate step in cellular respiration then there are overall 4 steps mentioned as under: 1) Glycolysis 2) Pyruvate decarboxylation 3) TCA or Citric acid cycle or Kreb cycle 4) Oxidative Phosphorylation. Glycolysis: During glycolysis from 1 glucose molecule, 2 ATP are used whereas 4 ATP molecules are produced so net ATP yield is 2 ATP. Apart from this, 2 NADH are also produced. So, during glycolysis overall we get 2 ATP and 2NADH from 1 glucose molecule. Pyruvate decarboxylation: During glycolysis 2 pyruvate molecules are produced from 1 glucose molecule. These pyruvate molecules are oxidatively decarboxylated in PDH complex. 2 pyruvate molecules produce 2 acetyl CoA molecules and 2 NADH at the end of pyruvate decarboxylation. TCA cycle/ tricarboxylic acid cycle/ Kreb cycle: The acetyl CoA produced as mentioned above then enters mitochondrial matrix. 1 acetyl CoA produces 3 NADH, 1 FADH2 and 1ATP/GTP so that means 2 acetyl CoA will produce 6 NADH, 2 FADH2 and 2 ATP/GTP. So in total we get, 2+2+6 = 10 NADH 2 FADH2 and 2+2 = 4 ATP Also, when 1 NADH undergoes Oxidative Phosphorylation then it produces 3 ATP so the total 10 NADH will produce = 10 x 3 = 30 ATP When 1 FADH2 undergoes Oxidative Phosphorylation then it produces 2 ATP so the total 2 FADH2 will produce = 2 x 2 = 4 ATP 4 ATP we get directly during the entire cellular respiration so, the total ATP yield from cellular respiration will be 30 + 4 + 4 = 38 ATP. The diagram is attached.