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Cephalosporin and penicillin, both acts on cell wall of bacteria. so how does cephalosporin act as a substitute for penicillin?
Cephalosporin and penicillin, both acts on cell wall of bacteria. So how can cephalosporin act as a substitute for penicillin?
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Abhijeet Gaurav![best-answer]()
Both are well established antibiotics. Cephalosporin is b-lactam rings constituting antibiotics which acts on Cell wall of bacteria. It is a broad- spectrum antibiotics because they are effective against a wide range of bacteria. It increases the risk of Clostridium difficile, MRSA and other resistant infections. Uncommonly, an overgrowth of the yeast, Candida albicans, may occur following cephalosporin use, resulting in the symptoms of thrush. Pencillin usually forms 5 membered Thiazolidine ring Whereas, Cephalosporin forms 6 membered Dihydothiazine ring. Pencillin shows less degradation as forms stable penicilloate ring. Has more suspectibility to b- lactamase Enzyme. Cephalosporin undergo rapid degradation of b- lactam & Dihydothiazine ring. Less suspectibility to b- lactamase Enzyme.