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Because the neurotransmitters are hydrophilic molecules, they are unable to cross the plasma membrane of their target cells. so they are bound to the cell surface receptors and provide response. Therefore, in contrast to steroid hormones and NO or CO can cross the plasma membrane so they have cytosolic or nuclear receptor and provide response according to the signalling molecules. ** The steroid hormones diffuse across the plasma membrane and bind to nuclear receptors, which directly stimulate transcription of their target genes. The steroid hormone receptors bind DNA as dimers. Ligand binding has distinct effects on different receptors.
neurotransmitters except peptides are synthesized in the presynaptic neuroterminals from the precursors by the synthesizing enzymes, stored in the synaptic vesicles, released by exocytosis into the synaptic cleft, combined with the postsynaptic membrane receptors, and induce a series of signal after binding.