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Anup Padwal Best Answer
It is stating the relation of nucleotide with water and each other. while reading this point assume the aqueous environment in cell. So free hydrogen donor or acceptor group of base pair face a problem , so they are unstable. As we know C6 of Adenine and C4 of Cytocine which are opposit and free so H2O will try to interact with them. which means opposite forces are acting on A and C which make 8t unstable.
so when the base pairing takes place between two complimentary base pairs like A and T, then what is the role of water molecule ! is it helping the DNA to make right pairs?
yes; unstability of Base due to water make nucleotide less stable when it finds the best match i.e A:T.