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Chanchal Kumar posted an Question
September 11, 2020 • 22:59 pm 30 points
  • IIT JAM
  • Biotechnology (BT)

I have a questions regarding t cells in reference to the screenshot attached

1.Do we have something called as (memory T cytotoxic cells ) , because as we know that the activation of Cd8+ and cd4+ T cells take place separately (after single negative maturation step in thymus) and we also know that after intraction with antigen they produce effector cd8 and effector cd4 cells along with the memory T cells (as showed in screenshot, but i never heard of the term 'memory cytotoxin T cells' ) why so ...do we only have momory T helper cells or both both of them exist(memory cytotoxin T cells and momory T helper cells)

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    Chanchal kumar Rathi

    And sir one more question ..as we consider T helper cells having a central role in humoral and cell mediated immunity... I have studied that T helper cells are involved in the activation of T cytotoxic cells (how?) and we know that for the activation of cytotoxic T cells they need to intract with antigen ...So my question is at the time of endogenous infection (1st time ) will they be activated directly after binding with the antigen(through MHC1) or they also require signalling from T helper cells as well

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    sir please spot some light on this as well

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    Anup Padwal best-answer

    Yes we have both T cytotoxic a d T helper cells. T cytotoxic: have CD2 and CD3 as receptor while CD8 a d CD28 as coreceptor. T helper: have same receptor but have CD4 instead of CD8. Also the T regulatory cells are also present. To generate longlasting memory T cells and to allow repetitive stimulation of cytotoxic T cells, dendritic cells have to interact with both, activated CD4+ helper T cells and CD8+ T cytotoxic cells. So no T memory cytotoxic cells.

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    And sir what about memory T helper cells ? what does they do in specific ...do they restimulate T helper cells only or other cells as well (cytotoxic T cells)\n\n\nSir can u please reedit the flowchart according to your saying

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    Can T helper cells be restimulated(from memory T cells (at the time of 2nd pathogenic invasion) )directly or they also have to intract with the dendritic(or macrophage) cell to restimulate T helper cells..

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    Actually both type of cell have some portion of cell in the body for some time. so the reinfection soon after infection, there is no need to interact with dendritic cells. but reinfection after long time will need dendritic cell.

    eduncle-logo-app

    you can say the t cytotoxic memory cell and t helper memory cells to the remaining portion of cells respectively.

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    sir so can i consider this flowchart correct for my understanding

    eduncle-logo-app

    yes it is correct.

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    thank you sir

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