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Arindam Paul posted an Question
August 28, 2020 • 19:17 pm 30 points
  • IIT JAM
  • Biotechnology (BT)

If in a cell cycle 2 spindle fibre binds with one centromere, can that be recognised by metaphase-anaphase checkpoint?

If in a cell cycle 2 spindle fibre binds with One Centromere, can that be recognised by Metaphase-Anaphase Checkpoint?

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    Narayan singh Best Answer

    yes that can be recognised by metaphase - anaphase check point or by APC (Anaphase promoting complex). APC recognised 2 spindle fibers are attached to centromere properly or not. if the spindle 2 fibers are not attached properly then mdm2 and BubR1 binds to the centromere and inhibit the APC. If spindle fibers attached to the centromere properly on then APC inhibit the function of securin (inhibitory unit of separase). when securin inhibit then separase activate which degrade cohsin protein. cohsin protein help in binding of chromatids at centromere. so the cohsin degrade and the chromosomes segregation start and the cell move from metaphase to Anaphase.

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    Anup Padwal best-answer

    if two or more than two spindal from arising from one pole binds with single chromosome it is considered as normal. but when two spindle from opposit pole binds with single chromosome it seperates sister chromatid. both type of events are observed in biological system. The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), or the mitotic checkpoint, is a cell cycle checkpoint during mitosis or meiosis that prevents the separation of the duplicated chromosomes (anaphase) until each chromosome is properly attached to the spindle fiber.

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