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Eduncle posted an MCQ
September 12, 2023 • 20:35 pm 0 points
  • CSIR NET
  • Life Sciences

Metachromatic leukodystrophy (MLD) is caused by a deficiency of arylsulfatase A and affects the CNS MLD is

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    Eduncle Best Answer

    Metachromatic leukodystrophy (MLD, also called arylsulfatase A deficiency) is a lysosomal storage disease which is commonly listed in the family of leukodystrophies as well as among the sphingolipidoses as it affects the metabolism of sphingolipide. Leukodystrophies affect the growth and/or development of myelin, the fatty covering which acts as an insulator around nerve fibers throughout the central and peripheral nervous systems. MLD involves cerebroside sulfate accumulation. Metachromatic leukodystrophy, like most enzyme deficiencies, has an autosomal recessive inheritance

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