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Quorum sensing is the regulation of gene expression in response to fluctuations in cell-population density. Quorum sensing bacteria produce and release chemical signal molecules called autoinducers that increase in concentration as a function of cell density Quorum sensing, mechanism by which bacteria regulate gene expression in accordance with population density through the use of signal molecules. ... For example, the bacterium Pseudomonas aeruginosa, which can cause pneumonia and blood infections, uses quorum sensing to regulate disease mechanisms. Quorum sensing (QS) is a cell density-dependent mechanism which enables a population of bacteria to coordinate cooperative behaviors in response to the accumulation of self-produced autoinducer signals in their local environment.