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Arindam Paul posted an Question
September 07, 2020 • 02:15 am 30 points
  • IIT JAM
  • Biotechnology (BT)

Sir please discuss about transcription factor ll h ?

Sir please discuss about Transcription Factor ll H ?

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    Anup Padwal Best Answer

    TFIIH: TFIIH is a multi-subunit protein complex consisting of two DNA helicases and a kinase domain (CAK) consisting of cyclin H. It functions in transcription by opening the promoter to allow RNAP initiation. TFIIH functions in NER by helping to open up the DNA around the lesion to allow damage verification. TFIIH through its kinase domain (CAK) is directly involved in cell cycle regulation. The two helicases within TFIIH play different roles. TFIIH unwinds the DNA about 20 nucleotide around the DNA lesions. It has been shown that it makes direct contact at the damaged site and its helicase activity is inhibited by damage.

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    Sir NER means?

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    its nucleotide excision repair mechanism.

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    Sir how many subunits are there? one book says 10, other says 9

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    10

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