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Nilanjan Bhowmick AIR 3, CSIR NET (Earth Science)
- IIT JAM
- Biotechnology (BT)
Tgate class switching occurs in a b-cell to produce igg from igm. which one of the following statements is correct? a. specificity of the igg and igm are differ
TGATE Class switching occurs in a B-cell to produce IgG from IgM. Which one of the following statements is correct? a. Specificity of the IgG and IgM are different from each other. b. Specificity of the IgG is the same as IgM. C. The molecular weight of the new antibody is the same as the old one. d. The valency of the new antibody is the same as the old one. [GATE]
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Narayan singh Best Answer
Ans is B. Immunoglobulin class switching (or isotype switching, or isotypic commutation, or class switch recombination (CSR)) is a biological mechanism that changes a B cell’s production of antibody from one class to another; for example, from an isotype called IgM to an isotype called IgG. During this process, the constant region portion of the antibody-heavy chain is changed, but the variable region of the heavy chain stays the same (the terms “constant” and “variable” refer to changes or lack thereof between antibodies that target different epitopes). Since the variable region does not change, class switching does not affect antigen specificity. Instead, the antibody retains affinity for the same antigens, but can interact with different effector molecules. This allows different daughter cells from the same activated B cell to produce antibodies of different isotypes or subtypes (e.g. IgG1, IgG2 etc.).