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Nilanjan Bhowmick AIR 3, CSIR NET (Earth Science)
Suryaprakash posted an Question
August 09, 2020 • 22:09 pm
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30 points
30 points
- IIT JAM
- Biotechnology (BT)
What does translesion of dna synthesis means ?
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Dhairya sharma
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Translesion DNA synthesis (TLS) isthe process by which cells copy DNAcontaining unrepaired damage that blocks progression of the replicationfork. The DNA polymerases that catalyze TLS in mammals have been the topic of intense investigation over the last decade.
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Anup Padwal
you can understand this concept in SOS repair mechanism. which is activated when extensive DNA damage. Due to Thiamine-Thiamine dimer which results from UV radiation Polymerase lll do not replicate damaged region. this damaged region are repaired by translession DNA polymarase which act as template independent DNA synthesis and add random nucleotide at damaged region this type of DNA synthesis is known as translession DNA synthesis. During this process to repair the DNA more damage may be cause.