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Mohanchaitanya Reddy posted an Question
April 29, 2020 • 17:56 pm
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30 points
30 points
- IIT JAM
- Biotechnology (BT)
Why hemoglobin and cytochromes are considered as chromoproteins instead of metalloproteins?
why hemoglobin and cytochromes are considered as chromoproteins instead of metalloproteins?
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Mohanchaitanya reddy
please don't copy and paste the lump sum of material.. i have read all of that.. my doubt is why hemoglobin is not considered as metalloprotein, it also contain Fe2+ in its core.
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Narayan singh
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A chromoprotein is a conjugated protein that contains a pigmented prosthetic group (or cofactor). A common example is haemoglobin, which contains a heme cofactor, which is the iron-containing molecule that makes oxygenated blood appear red. Other examples of chromoproteins include other hemochromes, cytochromes, phytochromes and flavoproteins. In hemoglobin there exists a chromoprotein (tetramer MW:4 x 16.125 =64.500), namely heme, consisting of Fe++ four pyrrol rings. Metalloprotein is a generic term for a protein that contains a metal ion cofactor. A large proportion of all proteins are part of this category. For instance, at least 1000 human proteins (out of ~20,000) contain zinc-binding protein domains although there may be up to 3000 human zinc metalloproteins that's why hemoglobin and cytochrome know as chromoprotein.
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Abhijeet Gaurav![best-answer]()
A chromoprotein is a conjugated protein that contains a pigmented prosthetic group (or cofactor). A common example is haemoglobin, which contains a heme cofactor, which is the iron-containing molecule that makes oxygenated blood appear red. Other examples of chromoproteins include other hemochromes, cytochromes, phytochromes and flavoproteins. Metalloprotein is a generic term for a protein that contains a metal ion cofactor.A large proportion of all proteins are part of this category. For instance, at least 1000 human proteins (out of ~20,000) contain zinc-binding protein domains although there may be up to 3000 human zinc metalloproteins. Hemoglobin & Cytochromes are both conjugated proteins & both are considered Metalloprotein as well as Chromoprotein. Cytochromes being pigmented & Hemoglobin too being pigmented are Chromoprotein and so they have Metal ion as the main cofactor is Metalloprotein even. So they are considered both not only Chromoprotein.